ATP Citrate Lyase

By Targets:	ATP Citrate Lyase (13) AMPK (3) Autophagy (1) Bacterial (2) Endogenous Metabolite (2) Fatty Acid Synthase (FASN) (1) Free Fatty Acid Receptor (1) HIF/HIF Prolyl-Hydroxylase (2)
By Research Areas:	Cancer (3) Infection (2) Inflammation/Immunology (2) Metabolic Disease (12)

Targets Recommended: ATP Citrate Lyase ATP Synthase P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16007

(-)-Hydroxycitric acid Garcinia acid	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of **ATP citrate lyase**. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss .

HY-16450

SB 204990 Maximum Cited Publications 13 Publications Verification	ATP Citrate Lyase	Metabolic Disease
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

HY-N12336

Gnetuhainin I	Others	Metabolic Disease
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC₅₀=2.63 μM) .

HY-N11781

Forrestiacids J

ATP Citrate Lyase Metabolic Disease

Forrestiacids J is an ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 2.6 μM .
HY-N11782

Forrestiacids K

ATP Citrate Lyase Others

Forrestiacids K, a terpenoid isolated from Pseudotsuga forrestii, acts as an ATP-citrate lyase (ACL) inhibitor .

Forrestiacids J	ATP Citrate Lyase	Metabolic Disease
Forrestiacids J is an ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 2.6 μM .

Forrestiacids K	ATP Citrate Lyase	Others
Forrestiacids K, a terpenoid isolated from Pseudotsuga forrestii, acts as an ATP-citrate lyase (ACL) inhibitor .

HY-16107

BMS-303141 Maximum Cited Publications 13 Publications Verification	ATP Citrate Lyase	Metabolic Disease
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 0.13 μM.

HY-12357

Bempedoic acid 5+ Cited Publications ETC-1002; ESP-55016	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor . Bempedoic acid (ETC-1002) activates AMPK .

HY-B1295

Lithium citrate tetrahydrate 2 Publications Verification Litarex tetrahydrate	ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology Cancer
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits **ATP citrate lyase** with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-127111

NDI-091143 2 Publications Verification	ATP Citrate Lyase	Cancer
NDI-091143 is a potent and high-affinity *human ATP-citrate* lyase (ACLY) inhibitor with an IC₅₀ of 2.1 nM (ADP-Glo assay), a K_i of 7.0 nM and a K_d of 2.2 nM. NDI-091143 inhibits ACLY** catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate .

HY-12357S2

Bempedoic acid-d4 ETC-1002-d₄; ESP-55016-d₄	ATP Citrate Lyase AMPK	Others
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of **ATP-citrate lyase*. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate* to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W009156

Citric acid tripotassium hydrate 2 Publications Verification Potassium Citrate monohydrate	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology Cancer
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits **ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF**, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-17640

Nicodicosapent	Fatty Acid Synthase (FASN) Autophagy	Metabolic Disease
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

HY-12357S

Bempedoic acid-d5 ETC-1002-d₅; ESP-55016-d₅	ATP Citrate Lyase AMPK	Metabolic Disease
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

HY-P1123

MEDICA16	ATP Citrate Lyase Free Fatty Acid Receptor	Metabolic Disease
MEDICA16, an **ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120** .

Cat. No.	Product Name	Type

HY-B1295

Lithium citrate tetrahydrate 2 Publications Verification Litarex tetrahydrate	Biochemical Assay Reagents
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits **ATP citrate lyase** with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16007

(-)-Hydroxycitric acid Garcinia acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Guttiferae Metabolic Disease Plants Garcinia cambogia Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of **ATP citrate lyase**. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss .

HY-B1295

Lithium citrate tetrahydrate 2 Publications Verification Litarex tetrahydrate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits **ATP citrate lyase** with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-N12336

Gnetuhainin I	Structural Classification Urticaceae Pouzolzia zeylanica (L.) Benn. Source classification Phenols Polyphenols Plants	Others
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC₅₀=2.63 μM) .

HY-N11781

Forrestiacids J	Triterpenes Structural Classification Classification of Application Fields Pinaceae Terpenoids Source classification Metabolic Disease Plants Pseudotsuga forrestii Craib Disease Research Fields	ATP Citrate Lyase
Forrestiacids J is an ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 2.6 μM .

HY-N11782

Forrestiacids K	Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Plants Pseudotsuga forrestii Craib	ATP Citrate Lyase
Forrestiacids K, a terpenoid isolated from Pseudotsuga forrestii, acts as an ATP-citrate lyase (ACL) inhibitor .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of **ATP-citrate lyase*. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate* to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W009156

Citric acid tripotassium hydrate 2 Publications Verification Potassium Citrate monohydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Guttiferae Metabolic Disease Plants Garcinia cambogia Inflammation/Immunology Disease Research Fields	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits **ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF**, and has antioxidation, anti-inflammation and anti-tumor effects .

Cat. No.	Compare	Product Name	Species	Source

HY-P72070

	ACLY Protein, Human (His-SUMO) ACL; Acly; ACLY_HUMAN; ATP Citrate pro-S; Lyase; ATP Citrate Lyase; ATP Citrate synthase; ATP-Citrate pro-S-; -Lyase; ATP-Citrate synthase; ATPCitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	E. coli
	ACLY Protein, Human (His-SUMO) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.


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Cat. No.	Product Name	Chemical Structure

HY-12357S2

Bempedoic acid-d4
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

HY-12357S

Bempedoic acid-d5
Bempedoic acid-d₅ is the deuterium labeled Bempedoic acid[1]. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].

Cat. No.	Product Name	Application	Reactivity

HY-P80380

ATP citrate lyase Antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
ATP citrate lyase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 121 kDa, targeting to ATP citrate lyase. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P80560

ATP Citrate Lyase Antibody (YA829) ACLY; ATP-Citrate synthase; ATP-Citrate; pro-S-)-Lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
ATP Citrate Lyase Antibody (YA829) is a non-conjugated and Mouse origined monoclonal antibody about 121 kDa, targeting to ATP Citrate Lyase (3D9). It can be used for WB,ICC/IF,FC assays with tag free, in the background of Human, Mouse, Monkey.

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ATP Citrate Lyase

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